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\documentclass[margin=5pt]{standalone}

\usepackage[ngerman]{babel}
\usepackage{pgfplots} % lädt tikz

\usepgfplotslibrary{units}

\pgfplotsset{
	compat=1.12,% für den Online-Editor, sonst 1.13
	/pgf/number format/.cd,
		use comma%,
%		1000 sep = {} 
}

\begin{document}
\begin{tikzpicture}
\begin{axis}[
	axis x line=bottom, axis y line=left, 
	xlabel=Zeit,
	ylabel=Beschriftung,
	xmin=0, xmax=540,
	ymin=59, ymax=62, 
	xtick={0,60,...,540},
	xticklabel={%
		\pgfmathdivide{\tick}{60}% ähnliches Beispiel mit \pgfmathparse im Abschnitt 4.15 der pgfplots-Dokumentation
		\pgfmathprintnumber{\pgfmathresult}%
	},
	x unit=min,
	width=0.9\textwidth, height=5cm
]
\addplot[mark=none, color=blue, smooth] table{Tab1.txt};
\end{axis}
\end{tikzpicture}
\end{document}

\documentclass[	12pt,							
			a4paper,  				
			]{scrreprt}												
\usepackage[ngerman]{babel}						
\usepackage{tikz}						
\usepackage{pgfplots}


\begin{document}


\begin{figure}
\centering
\begin{tikzpicture}
\begin{axis}[axis x line=bottom, axis y line=left, 
			xlabel= Zeit, xmin=0, 
			ylabel= Beschriftung, ymin=59, ymax=62, 
			width=0.9\textwidth, height=5cm,
			/pgf/number format/.cd, use comma, 1000 sep = {} 
			]
\addplot[mark=, color=blue, smooth] table{Tab1.txt};
\end{axis}
\end{tikzpicture}
\caption{Bildunterschrift}
\label{referenz}
\end{figure}


\end{document}